Cluster headache: A prospective clinical study with diagnostic implications

  title={Cluster headache: A prospective clinical study with diagnostic implications},
  author={Anish Bahra and Arne May and Peter J. Goadsby},
BackgroundCluster headache, when compared with migraine or tension-type headache, is an uncommon form of primary neurovascular headache. However, with a prevalence of approximately 0.1% and a lengthy history of disabling and distressing episodic pain, cluster headache is an important neurologic problem. MethodsPatients (n = 230) were recruited from our specialist clinic (24%) or from support groups (76%). All patients had a detailed history taken by at least two physicians and were assigned… 
Cluster headache in Greece: an observational clinical and demographic study of 302 patients
Cluster headache, in a large cohort of Greek patients, has the same phenotypic characteristics as described internationally, and uncommon clinical features do exist and physicians should be aware of those, since they may eventuate in diagnostic problems.
Cluster headache: a single tertiary center study
Clinical features of patients diagnosed with cluster headache in Turkey were similar to those of Europe and America or the Asian countries and some of them not, and there are regional differences in cluster headache patients.
Cluster Headache: Epidemiology, Pathophysiology, Clinical Features, and Diagnosis
The pathophysiology involves activation of the trigeminovascular complex and the trigeminal-autonomic reflex and accounts for the unilateral severe headache, the prominent ipsilateral cranial autonomic symptoms, and the circadian and circannual rhythmicity unique to this condition.
Genetic aspects of cluster headache
Collaborative multicenter studies on large clinically well-defined materials are needed to reach a better understanding of the complex genetic background of CH.
Cluster Headache in the Taiwanese — a Clinic-Based Study
Compared to Western series, the authors' patients were different in several aspects including the absence of chronic cluster headaches and a low prevalence of restlessness and aura and racial and geographical factors might contribute to these discrepancies.
Recent advances in the diagnosis and management of cluster headache
Clinical, pathophysiologic, and therapeutic features of cluster headache are reviewed, which include new treatments for episodic cluster headache (galcanezumab and non-invasive vagus nerve stimulation) and recent updates in diagnosis include the redefinition of chronic cluster headache.
Medication-overuse headache in patients with cluster headache
Medication-overuse headache is a previously underrecognized and treatable problem associated with cluster headache (CH).
Approach to acute headache in adults.
A thorough history and physical examination, and an understanding of the typical features of primary headaches, can reduce the need for neuroimaging, lumbar puncture, or other studies.
Diagnostic and therapeutic trajectory of cluster headache patients in Flanders.
The need for better medical education on CH is evident to optimize CH management in Flanders, and specific data for Flanders is warranted.
Features involved in the diagnostic delay of cluster headache
Cluster headache remains unrecognised or misdiagnosed in many cases for many years, and should be recognised as part of the clinical spectrum of CH.


Cluster headache: a review
  • A. Krabbe
  • Medicine
    Acta neurologica Scandinavica
  • 1986
Cluster headache is a rare headache entity that predominantly occurs in younger males, characterized by sudden attacks of unilateral excruciating pain localized periorbitally, associated with ipsilateral autonomic symptoms.
Cluster Headache — Clinical Findings in 180 Patients
The study of timing of cluster periods suggests, for some patients, a constant, typical temporal pattern not necessarily related to seasons or the months of the year, and cluster headache cannot be considered as a nocturnal headache.
Migrainous neuralgia or cluster headache?
The Family History of Migraine. Direct Versus Indirect Information
Migraine assessed by proband report is not satisfactory for diagnosing migraine in relatives, since the number of affected relatives is highly underestimated, and the necessity of a clinical interview of the relatives in family studies of migraine is emphasized.
Clinical observations on 76 cluster headache cases.
The peculiar behaviour of patients during the attacks does not appear explainable in simple terms of reaction to pain, but the time relationship with REM sleep stage is confirmed in cases which have been recorded at night.
The Trigeminovascular System in Humans: Pathophysiologic Implications for Primary Headache Syndromes of the Neural Influences on the Cerebral Circulation
  • A. May, P. Goadsby
  • Medicine, Psychology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 1999
It is taken the view that these disorders should be collectively regarded as neurovascular headaches to emphasize the interaction between nerves and vessels, which is the underlying characteristic of these syndromes.
  • K. Ekbom
  • Psychology, Medicine
  • 1974
The hypothesis that basic etiological differences exist between the two conditions of cluster headache and migraine is supported.
Heritability of cluster headache
A higher familial occurrence of CH is confirmed, some families showing a pattern compatible with autosomal dominant inheritance with reduced penetrance, and the low Falconer's index indicates, however, a large non‐genetic causation in most cases of CH.
Cluster Headache in Women: Evidence of Hypofertility(?) Headaches in Relation to Menstruation and Pregnancy
Parity rate was low in patients who contracted cluster headache as nulliparae; it was higher than in those who contracted the disease after earlier pregnancy or post menopause, and also significantly lower than in 99 consecutive women with migraine.