Cluster analysis of genome-wide expression differences in disease-unaffected ileal mucosa in inflammatory bowel diseases

@article{Zhang2011ClusterAO,
  title={Cluster analysis of genome-wide expression differences in disease-unaffected ileal mucosa in inflammatory bowel diseases},
  author={Tianyi Zhang and Robert A. DeSimone and Hongyan Chen and Christina M. Hamm and Jeffrey Yuan and Qing Qing Gong and Steven R. Hunt and Themistocles Dassopoulos and Rodney D. Newberry and Daniel N. Frank and Charles E. Robertson and Norman R. Pace and Erica Sodergren and George Weinstock and Xiangmin Jiao and Wei Zhu and Ellen Li},
  journal={2011 IEEE 1st International Conference on Computational Advances in Bio and Medical Sciences (ICCABS)},
  year={2011},
  pages={220-225}
}
Whole human genome (Agilent) expression profiling was conducted on disease-unaffected ileal RNA collected from the proximal margin of resected ileum from 47 ileal Crohn's disease (CD), 27 ulcerative colitis (UC) and 25 control patients without inflammatory bowel diseases (IBD). Cluster analysis combined with significance analysis of microarrays (SAM) and principal component analysis (PCA) and was used to reduce the data dimension to identify geneprobe clusters associated with early pathogenic… CONTINUE READING

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