Cluster Headache

  title={Cluster Headache},
  author={Manjit Singh Matharu and Peter J. Goadsby},
  journal={Practical Neurology},
  pages={42 - 49}
Cluster headache (CH) is a strictly unilateral headache that occurs in association with cranial autonomic features and, in most patients, has a striking circannual and circadian periodicity. It is an excruciating syndrome and is probably one of the most painful conditions known to mankind, with female patients describing each attack as being worse than childbirth. The understanding of cluster headache, in pathophysiological terms, and the management strategies, have altered dramatically in… 

Trigeminal Autonomic Cephalalgias.

Valvular heart disease associated with long-term treatment by methysergide: a case report.

The echocardiographic and histological features of the severe valve fibrosis presented by this patient are very similar to those described with 5 HT(2B) receptors agonistic drugs.

Capsaicin inhibits glycolysis in esophageal squamous cell carcinoma by regulating hexokinase‑2 expression.

It is demonstrated that capsaicin exhibited an inhibitory effect on tumor glycolysis in esophageal squamous cell carcinoma (ESCC) cells and the RAC‑α serine threonine‑protein kinase signaling pathway was downregulated.



Hypothalamic activation in cluster headache attacks

Cluster headache and related conditions

This volume of Frontiers in Headache Research is the only up-to-date and comprehensive review of the condition and its related disorders and looks at the wealth of basic research into cluster headache.

Cluster headache with aura

The frequency and characteristics of cluster headaches with aura among the population of patients with cluster headache treated in an outpatient neurology clinic suggest the participation of the central nervous system in this type of cluster headache.

PET and MRA findings in cluster headache and MRA in experimental pain

Dilatation of cranial vessels is not specific to any particular headache syndrome but generic to cranial neurovascular activation, probably mediated by the trigeminoparasympathetic reflex.

Topiramate-treated cluster headache

Clinical findings in 10 cluster headache patients whose conditions improved when they took topiramate are reported, and the mechanism for this response may be related to gamma-aminobutyric acid augmentation.

Cluster Headache Course Over Ten Years in 189 Patients

One-hundred-and-eighty-nine cluster headache patients, referred to Parma and Pavia Headache Centres between 1976 and 1986 with a disease duration of over 10 years, were interviewed about the course

Correlation between structural and functional changes in brain in an idiopathic headache syndrome

The results indicate that the current view of the neurobiology of cluster headache requires complete revision and that this periodic headache is associated with a hitherto unrecognized brain abnormality in the hypothalamic region.

Sumatriptan in Chronic Cluster Headache: Results of Continuous Treatment for Eleven Months

It is concluded that sumatriptan in this case was an effective and well-tolerated treatment for cluster headache.

Oral zolmitriptan is effective in the acute treatment of cluster headache

To the Editor: I read with interest the trial by Bahra et al.1 on the treatment of acute cluster headache with oral zolmitriptan, in which they found a modest but significant difference between the

Gender Ratio of Cluster Headache Over the Years: A Possible Role of Changes in Lifestyle

  • G. Manzoni
  • Medicine
    Cephalalgia : an international journal of headache
  • 1998
Changes in the male-to-female (M/F) ratio of cluster headache over the years were investigated through a comparative analysis of the distribution of the disease by sex and decade of onset in 482 patients, suggesting that the significant changes that have occurred over the last few decades in the lifestyle of both sexes may have played a major role in altering the gender ratio of CH.