Cluster Analysis of Tumor Suppressor Genes in Canine Leukocytes Identifies Activation State

@inproceedings{Daly2015ClusterAO,
  title={Cluster Analysis of Tumor Suppressor Genes in Canine Leukocytes Identifies Activation State},
  author={Julie-Anne Daly and Sally-Anne Mortlock and Rosanne Maree Taylor and Peter R. Williamson},
  booktitle={Bioinformatics and biology insights},
  year={2015}
}
Cells of the immune system undergo activation and subsequent proliferation in the normal course of an immune response. Infrequently, the molecular and cellular events that underlie the mechanisms of proliferation are dysregulated and may lead to oncogenesis, leading to tumor formation. The most common forms of immunological cancers are lymphomas, which in dogs account for 8%-20% of all cancers, affecting up to 1.2% of the dog population. Key genes involved in negatively regulating proliferation… CONTINUE READING