Clumping factor A interaction with complement factor I increases C3b cleavage on the bacterial surface of Staphylococcus aureus and decreases complement-mediated phagocytosis.

@article{Hair2010ClumpingFA,
  title={Clumping factor A interaction with complement factor I increases C3b cleavage on the bacterial surface of Staphylococcus aureus and decreases complement-mediated phagocytosis.},
  author={Pamela S. Hair and Charlene G. Echague and Amber M Sholl and Justin Watkins and Joan A Geoghegan and Timothy Foster and Kenji M Cunnion},
  journal={Infection and immunity},
  year={2010},
  volume={78 4},
  pages={
          1717-27
        }
}
The human complement system is important in the immunological control of Staphylococcus aureus infection. We showed previously that S. aureus surface protein clumping factor A (ClfA), when expressed in recombinant form, bound complement control protein factor I and increased factor I cleavage of C3b to iC3b. In the present study, we show that, compared to the results for the wild type, when isogenic ClfA-deficient S. aureus mutants were incubated in serum, they bound less factor I, generated… CONTINUE READING

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