Clubbing and hypertrophic osteoarthropathy: insights in diagnosis, pathophysiology, and clinical significance.

@article{Callemeyn2016ClubbingAH,
  title={Clubbing and hypertrophic osteoarthropathy: insights in diagnosis, pathophysiology, and clinical significance.},
  author={Jasper Callemeyn and Peter Van Haecke and Willy E. Peetermans and Daniel Blockmans},
  journal={Acta clinica Belgica},
  year={2016},
  volume={71 3},
  pages={123-30}
}
BACKGROUND Digital clubbing and hypertrophic osteoarthropathy (HOA) form a diagnostic challenge. Subtle presentations of clubbing are often missed. The underlying pathophysiology remains unclear. Establishing a differential diagnosis based on nonspecific signs can be cumbersome. Finally, the prognostic value of clubbing and HOA remains unclear. OBJECTIVE This article reviews clinical criteria and pathophysiology of clubbing and HOA. A diagnostic algorithm is proposed, based on etiology and… CONTINUE READING
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