Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.

@article{Zhang2011Clr4Suv39AR,
  title={Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.},
  author={Ke Zhang and Tam{\'a}s Fischer and Rebecca L. Porter and Jothy Dhakshnamoorthy and Martin Zofall and Ming Zhou and Timothy D. Veenstra and Shiv I S Grewal},
  journal={Science},
  year={2011},
  volume={331 6024},
  pages={1624-7}
}
Pervasive transcription of eukaryotic genomes generates a plethora of noncoding RNAs. In fission yeast, the heterochromatin factor Clr4/Suv39 methyltransferase facilitates RNA interference (RNAi)-mediated processing of centromeric transcripts into small interfering RNAs (siRNAs). Clr4 also mediates degradation of antisense RNAs at euchromatic loci, but the underlying mechanism has remained elusive. We show that Clr4 and the RNAi effector RITS (RNA-induced transcriptional silencing) interact… CONTINUE READING
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