ClpV recycles VipA/VipB tubules and prevents non-productive tubule formation to ensure efficient type VI protein secretion.

@article{Kapitein2013ClpVRV,
  title={ClpV recycles VipA/VipB tubules and prevents non-productive tubule formation to ensure efficient type VI protein secretion.},
  author={Nicole Kapitein and Gabriele B{\"o}nemann and Aleksandra Pietrosiuk and Fabian Seyffer and Ingrid Hausser and Jacomine Krijnse Locker and Axel Mogk},
  journal={Molecular microbiology},
  year={2013},
  volume={87 5},
  pages={1013-28}
}
The multicomponent type VI secretion system (T6SS) mediates the transport of effector proteins by puncturing target membranes. T6SSs are suggested to form a contractile nanomachine, functioning similar to the cell-puncturing device of tailed bacteriophages. The T6SS members VipA/VipB form tubular complexes and are predicted to function in analogy to viral tail sheath proteins by providing the energy for secretion via contraction. The ATPase ClpV disassembles VipA/VipB tubules in vitro, but the… CONTINUE READING
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