Clozapine withdrawal effects and receptor profiles of typical and atypical neuroleptics

  title={Clozapine withdrawal effects and receptor profiles of typical and atypical neuroleptics},
  author={C. Verghese and J. Deleon and C. Nair and G. Simpson},
  journal={Biological Psychiatry},
  • C. Verghese, J. Deleon, +1 author G. Simpson
  • Published 1996
  • Psychology, Medicine
  • Biological Psychiatry
  • Withdrawal effects of neuroleptics have not received much attention. Clozapine withdrawal phenomena have been attributed to psychosis arising from D2 supersensitivity, which is unlikely since it has minimal action on D2 receptors. The time course and clinical features of this phenomenon suggest that cholinergic overdrive and gamma-aminobutyric acid (GABA) supersensitivity occurs after withdrawal, since it is strongly anticholinergic and has a GABAergic action. Recently, a number of patients… CONTINUE READING
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