Clozapine versus "high-dose" olanzapine in refractory early-onset schizophrenia: an open-label extension study.

@article{Kumra2008ClozapineV,
  title={Clozapine versus "high-dose" olanzapine in refractory early-onset schizophrenia: an open-label extension study.},
  author={Sanjiv Kumra and Harvey N Kranzler and Ginny Gerbino-Rosen and Hana M Kester and Courtney DeThomas and Kathyrn Cullen and James B Regan and John M. Kane},
  journal={Journal of child and adolescent psychopharmacology},
  year={2008},
  volume={18 4},
  pages={307-16}
}
OBJECTIVE A recent 12-week controlled comparison demonstrated the superiority of clozapine to "high-dose" olanzapine in adolescents with treatment-refractory schizophrenia. In the present study, the authors conducted a 12-week, open-label, follow-up study to examine changes in lipid and glucose metabolism in youths maintained on clozapine and to determine whether patients who were previously randomized to high-dose olanzapine (up to 30 mg/day) responded to clozapine. METHOD Thirty three (14… CONTINUE READING

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