Clozapine treatment of borderline patients: a preliminary study.

  title={Clozapine treatment of borderline patients: a preliminary study.},
  author={Frances Rachel Frankenburg and Mary C. Zanarini},
  journal={Comprehensive psychiatry},
  volume={34 6},
Clinicians frequently encounter patients who present with borderline personality disorder (BPD) and prolonged and/or pronounced psychotic symptoms of an atypical nature. Fifteen such patients were treated with clozapine and rerated blind to baseline symptomatology and functional level from 2 to 9 months after beginning treatment (mean = 4.2 +/- 2.1). The overall symptomatology of these patients as rated on the Brief Psychiatric Rating Scale (BPRS) decreased significantly from a mean of 57.0… CONTINUE READING


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