Clozapine therapy raises serum concentrations of high sensitive C-reactive protein in schizophrenic patients.

@article{Loeffler2010ClozapineTR,
  title={Clozapine therapy raises serum concentrations of high sensitive C-reactive protein in schizophrenic patients.},
  author={Stefan Loeffler and Mignon L{\"o}ffler-Ensgraber and Karin Fehsel and Ansgar Klimke},
  journal={International clinical psychopharmacology},
  year={2010},
  volume={25 2},
  pages={101-6}
}
Eight schizophrenic inpatients without manifest comorbidity were longitudinally studied. The aim was to find whether clozapine, the prototype of atypical antipsychotic drugs, altered their serum concentrations of high sensitive C-reactive protein (hsCRP), an inflammatory marker of high clinical importance. Following first-time therapy with clozapine, predominantly as the sole antipsychotic for 8 weeks, hsCRP profiles increased subclinically by 600%. This rise, and the Spearman correlation… CONTINUE READING