Clozapine pharmacokinetics and pharmacodynamics studied with Cyp1A2-null mice.

  title={Clozapine pharmacokinetics and pharmacodynamics studied with Cyp1A2-null mice.},
  author={Katherine J Aitchison and Michael W. Jann and Jian-hong Zhao and Toshio Sakai and Hani Zaher and K Wolff and David A. Collier and Robert W. Kerwin and Frank J. Gonzalez},
  journal={Journal of psychopharmacology},
  volume={14 4},
The aim of this study was to use the CYP1A2-null mouse to investigate the in-vivo contribution of CYP1A2 to clozapine pharmacokinetics and pharmacodynamics. An intraperitoneal injection of 10 mg/kg clozapine was administered to four male CYP1A2 -/- mice and four male wild-type mice. Clozapine, desmethylclozapine, and clozapine N-oxide concentrations in sequential tail blood samples were measured by HPLC with UV detection. Behavioural parameters were recorded at each time point. The area under… CONTINUE READING

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