Clozapine-induced weight gain associated with the 5HT2C receptor -759C/T polymorphism.

@article{Miller2005ClozapineinducedWG,
  title={Clozapine-induced weight gain associated with the 5HT2C receptor -759C/T polymorphism.},
  author={Del D. Miller and Vicki L Ellingrod and Timothy L Holman and Peter Buckley and Stephan Arndt},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2005},
  volume={133B 1},
  pages={97-100}
}
Weight gain has been documented as a significant adverse effect associated with many of the atypical antipsychotic medications. Several recent reports have linked a -759C/T polymorphism of the 5HT2C receptor gene and obesity as well as chlorpromazine, risperidone, and clozapine induced to weight gain. This aim was to determine the association between changes in body mass index (BMI) during clozapine treatment and the -759C/T polymorphism of the 5HT2C receptor gene. This study included 41… CONTINUE READING