Clozapine-induced seizures and EEG changes.

  title={Clozapine-induced seizures and EEG changes.},
  author={Jenni Welch and Theo C. Manschreck and Deidre L Redmond},
  journal={The Journal of neuropsychiatry and clinical neurosciences},
  volume={6 3},
Clozapine, an atypical antipsychotic drug, is widely used in refractory schizophrenia. At New Hampshire Hospital, 7 of the first 35 patients treated (20%) had convulsions. Patterns were tonic-clonic (5), complex partial (2), and myoclonic (3). Seizures were dose-related and may be anticholinergic in etiology. EEG changes are frequent with clozapine, particularly as dosage is increased. Twenty-six of 35 patients (74%) had EEG abnormalities at some time during clozapine treatment. EEG is a… CONTINUE READING