Clozapine-induced alteration of glucose homeostasis in the rat: the contribution of hypothalamic-pituitary-adrenal axis activation.

@article{Tulipano2007ClozapineinducedAO,
  title={Clozapine-induced alteration of glucose homeostasis in the rat: the contribution of hypothalamic-pituitary-adrenal axis activation.},
  author={Giovanni Tulipano and Cristina Rizzetti and Irene Bianchi and Alessandro Fanzani and PierFranco Spano and Daniela Cocchi},
  journal={Neuroendocrinology},
  year={2007},
  volume={85 2},
  pages={
          61-70
        }
}
BACKGROUND/AIMS To our knowledge, a suitable animal model to investigate how atypical antipsychotics may induce diabetes in patients has not received much attention. METHODS We investigated the effects of acute as well as subchronic administration of clozapine on food intake, body weight gain, glucose tolerance and insulin secretion in response to glucose in Sprague-Dawley rats. We then evaluated the effects of clozapine on corticosterone secretion and 11beta-hydroxysteroid dehydrogenase type… CONTINUE READING
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