Clozapine in Special Hospital: a retrospective case-control study

@article{Swinton2000ClozapineIS,
  title={Clozapine in Special Hospital: a retrospective case-control study},
  author={Mark Swinton and A. Haddock},
  journal={The Journal of Forensic Psychiatry},
  year={2000},
  volume={11},
  pages={587 - 596}
}
  • M. SwintonA. Haddock
  • Published 1 January 2000
  • Psychology, Medicine
  • The Journal of Forensic Psychiatry
Clozapine has been conclusively shown to be more effective than other drugs in reducing positive and negative symptoms of schizophrenia. There is, however, little evidence that it has any effect on length of stay in hospital. There is also little information on its use in Special Hospital (highsecurity) settings. This study investigated the impact of Clozapine on the need for Special Hospital care. A retrospective case-control design was used. All the patients ever treated continuously with… 

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References

SHOWING 1-5 OF 5 REFERENCES

Evidence of clozapine's effectiveness in schizophrenia: a systematic review and meta-analysis of randomized trials.

This meta-analysis confirms that clozapine is more effective than conventional neuroleptics in reducing symptoms of patients with both treatment-resistant and nonresistant schizophrenia.

Reasons for non‐prescription of clozapine in treatment‐resistant schizophrenia

A significant proportion of patients in Ashworth Hospital with schizophrenia or schizoaffective psychosis who had never been prescribed clozapine were assessed using the PANSS and the NOSIE and by interviews.

Schizophrenia, Violence, Clozapine and Risperidone: a Review

There is no longer much doubt that there is a small but real association between psychosis and violence directed at others, as well as between psychosis and self-directed violence, including suicide.

Clozapine Treatment of Longstanding Schizophrenia and Serious Violence

  • Criminal Behaviour and Mental Health
  • 1999