Clozapine for comorbid substance use disorder and schizophrenia: do patients with schizophrenia have a reward-deficiency syndrome that can be ameliorated by clozapine?

@article{Green1999ClozapineFC,
  title={Clozapine for comorbid substance use disorder and schizophrenia: do patients with schizophrenia have a reward-deficiency syndrome that can be ameliorated by clozapine?},
  author={Alan I. Green and Suzannah V Zimmet and Rael David Strous and Joseph J. Schildkraut},
  journal={Harvard review of psychiatry},
  year={1999},
  volume={6 6},
  pages={287-96}
}
Alcohol and other drugs of abuse are commonly used by persons with schizophrenia and contribute to the overall morbidity of the disorder. Standard, or typical, antipsychotic drugs do not limit such substance use and may even render it more likely. However, preliminary data from our group and others suggest that the atypical antipsychotic clozapine may decrease substance use in this population. While recognizing the likelihood that substance use decreases negative symptoms (as well as… CONTINUE READING

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