Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test.

  title={Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test.},
  author={Leif Bertilsson and Juan Antonio Cabrera Carrillo and Marja Liisa Dahl and Adri{\'a}n Llerena and Christina Alm and U. G. Bondesson and Leif Lindstr{\"o}m and I Rodriguez de la Rubia and Sara Isabel Ramos and Julio Cesar Munoz Benitez},
  journal={British journal of clinical pharmacology},
  volume={38 5},
In a previous study we showed that the disposition of clozapine after a single oral dose is unrelated to either debrisoquine or S-mephenytoin hydroxylation polymorphism. The same 14 healthy subjects studied in that investigation were given 150 mg of caffeine. The reciprocal of plasma clozapine AUC (0,24), was correlated with an index of the N3-demethylation of caffeine (rs = 0.84; P = 0.0024), used as a measure of cytochrome P4501A2 (CYP1A2) activity. N1- and N7-demethylation indices of… CONTINUE READING

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Fluvoxamine is a potent inhibitor of cytochrome P 4501 A 2

  • E Skjelbo, BB Rasmussen, HE Poulsen, S Loft
  • Biochem Pharmac
  • 1993

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