Clozapine can induce high dopamine D2 receptor occupancy in vivo

Abstract

Rationale: Clozapine is a unique antipsychotic with very low propensity to cause motor side effects. In contrast to most other antipsychotics that block more than 70% of dopamine D2 receptors at therapeutic doses, clozapine occupies less than 70%. Furthermore, even at maximum occupancy, 70% is not exceeded. Several mechanisms have been proposed as… (More)
DOI: 10.1007/s00213-001-0967-0

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