Clozapine but not haloperidol suppresses the changes in the levels of neuropeptides in MK-801-treated rat brain regions.

Abstract

Noncompetitive NMDA receptor antagonist (+)MK-801 is known to induce neurotoxicity and schizophrenia-like symptomatology where atypical neuroleptic clozapine is effective in contrast to typical neuroleptic, haloperidol. Although neuropeptides are implicated in memory and cognition, their roles in schizophrenia are not well understood. In the present study… (More)

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