Clozapine blocks dopamine, 5-HT2 and 5-HT3 responses in the medial prefrontal cortex: an in vivo microiontophoretic study

@article{Gobbi1999ClozapineBD,
  title={Clozapine blocks dopamine, 5-HT2 and 5-HT3 responses in the medial prefrontal cortex: an in vivo microiontophoretic study},
  author={Gabriella Gobbi and Luigi Janiri},
  journal={European Neuropsychopharmacology},
  year={1999},
  volume={10},
  pages={43-49}
}
  • G. Gobbi, L. Janiri
  • Published 1999
  • Medicine, Psychology
  • European Neuropsychopharmacology
Clozapine is an atypical antipsychotic drug active on both positive and negative symptoms of schizophrenia which has a unique serotonergic and dopaminergic profile. Given the putative role of the medial prefrontal cortex (mPFC) in negative symptoms of schizophrenia, the aim of this study was to assess the effects of clozapine on the dopamine- and serotonin-responsive neurons in that particular brain structure. D1 and D2 agonists (SKF 38393 and quinpirole) as well as 5-HT2 and 5-HT3 agonists (1… Expand
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