Clozapine blocks dopamine, 5-HT2 and 5-HT3 responses in the medial prefrontal cortex: an in vivo microiontophoretic study

  title={Clozapine blocks dopamine, 5-HT2 and 5-HT3 responses in the medial prefrontal cortex: an in vivo microiontophoretic study},
  author={Gabriella Gobbi and Luigi Janiri},
  journal={European Neuropsychopharmacology},
  • G. Gobbi, L. Janiri
  • Published 1 December 1999
  • Psychology, Biology, Medicine
  • European Neuropsychopharmacology

Hyperlocomotive and Discriminative Stimulus Effects of Cocaine Are Under the Control of Serotonin2C (5-HT2C) Receptors in Rat Prefrontal Cortex

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Functional Changes of Orexinergic Reaction to Psychoactive Substances

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Effect of atypical antipsychotic drugs on 5-HT2 receptors in the rat orbito-frontal cortex: an in vivo electrophysiological study

The results suggest that the 5-HT2 response in the OFc is more akin to the 5,HT2C subtype and that the deleterious effect sometimes observed with high doses of risperidone and clozapine may be due to a decrease in 5- HT neurotransmission.

Pharmacological characterization of the receptor mediating electrophysiological responses to dopamine in the rat medial prefrontal cortex: a microiontophoretic study.

  • S. SesackB. Bunney
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1989
Results indicate that the receptor mediating the inhibitory effects of DA in the medial PFC has the pharmacological characteristics of a D2 subtype, however, this receptor may not be identical to D2 sites in other brain regions.

The role of 5-HT3-like receptors in the action of clozapine.

It is hypothesized that the preferential action of clozapine on the mesocorticolimbic dopamine system is the result of the drug's interaction with the 5-HT3-like receptors, and the antagonizing effect of clazapine to 5- HT3- like receptors may contribute to its increased antipsychotic efficacy.

Action of serotonin in the medial prefrontal cortex: Mediation by serotonin3‐like receptors

5‐HT's physiological effect in the mPFc may be primarily mediated by its interaction with 5‐HT3‐like receptors and that ritanserin's blockade of CLi‐induced suppression of m PFc cell firing may be indirect.

Electrophysiological effects of selective D1 and D2 dopamine receptor agonists in the medial prefrontal cortex of young and aged Fischer 344 rats.

It is suggested that both D1 and D2 receptors are present in the PFC and that agonist occupancy of each of these receptors elicits an inhibition of PFC neuron discharge, and an age-related change in D1 dopamine receptor-mediated processes with no concomitant change in processes linked to the activation of D2 dopamine processes is suggested.

Electrophysiological characterization of 5-hydroxytryptamine2 receptors in the rat medial prefrontal cortex.

Overall the results indicate that DOI predominantly inhibits mPFc cells in a direct manner and this effect is mediated by 5-HT2 receptors.

Comparison of the effects of various typical and atypical antipsychotic drugs on the suppressant action of 2‐methylserotonin on medial prefrontal cortical cells in the rat

The results suggest that the majority of putative atypical APDs do not interact with 5‐HT3 binding sites in the brain.