Clozapine blocks dopamine, 5-HT2 and 5-HT3 responses in the medial prefrontal cortex: an in vivo microiontophoretic study

@article{Gobbi1999ClozapineBD,
  title={Clozapine blocks dopamine, 5-HT2 and 5-HT3 responses in the medial prefrontal cortex: an in vivo microiontophoretic study},
  author={Gabriella Gobbi and Luigi Janiri},
  journal={European Neuropsychopharmacology},
  year={1999},
  volume={10},
  pages={43-49}
}
  • G. Gobbi, L. Janiri
  • Published 1 December 1999
  • Psychology, Biology, Medicine
  • European Neuropsychopharmacology

Hyperlocomotive and Discriminative Stimulus Effects of Cocaine Are Under the Control of Serotonin2C (5-HT2C) Receptors in Rat Prefrontal Cortex

TLDR
The data indicate that the PFC is a brain site at which the 5-HT2CR exerts an inhibitory control over the hyperactive and discriminative stimulus effects of cocaine known to be dependent upon activation of the DA mesoaccumbens circuit.

Sodium- and magnesium-valproate in vivo modulate glutamatergic and GABAergic synapses in the medial prefrontal cortex

TLDR
Data suggest that VPA salts significantly modulate the activity of excitatory amino acid at mPFC pyramidal neurons and this mechanism should explain the therapeutic effects of valproate in psychiatric diseases involving NMDA, AMPA, and kainate receptors at the mP FC level.

5‐HT2C receptor antagonists: Potential in schizophrenia

TLDR
The role of the 5‐HT2C receptor in both the therapeutic profile of atypical antipsychotics and in the regulation of the dopaminergic system is focused on.

Differential effects of 5-HT2A and 5-HT2C receptor blockade on strategy-switching

The Psychopharmacology of Aggressive Behavior: A Translational Approach Part 2 Clinical Studies Using Atypical Antipsychotics, Anticonvulsants, and Lithium

TLDR
A critical review of all clinical trials using atypical antipsychotics, anticonvulsants, and lithium shows that a multifunctional combined therapy, targeting different receptors, seems to be the best strategy for treating aggressive behavior.

Functional Changes of Orexinergic Reaction to Psychoactive Substances

TLDR
The aim of this paper is to assess the influence of orexin A on sympathetic and hyperthermic reactions to several neuroleptic drugs and determine that neuroleptics mediate body temperature control through to the orexInergic system.

New targets for antipsychotics

TLDR
This research in receptor pharmacology is set in the context of theincreasingly recognised importance of the clinical care for patients with first onset schizophrenia and recent developments in pharmacogenomics.

References

SHOWING 1-10 OF 31 REFERENCES

Effect of atypical antipsychotic drugs on 5-HT2 receptors in the rat orbito-frontal cortex: an in vivo electrophysiological study

TLDR
The results suggest that the 5-HT2 response in the OFc is more akin to the 5,HT2C subtype and that the deleterious effect sometimes observed with high doses of risperidone and clozapine may be due to a decrease in 5- HT neurotransmission.

Pharmacological characterization of the receptor mediating electrophysiological responses to dopamine in the rat medial prefrontal cortex: a microiontophoretic study.

  • S. SesackB. Bunney
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1989
TLDR
Results indicate that the receptor mediating the inhibitory effects of DA in the medial PFC has the pharmacological characteristics of a D2 subtype, however, this receptor may not be identical to D2 sites in other brain regions.

The role of 5-HT3-like receptors in the action of clozapine.

TLDR
It is hypothesized that the preferential action of clozapine on the mesocorticolimbic dopamine system is the result of the drug's interaction with the 5-HT3-like receptors, and the antagonizing effect of clazapine to 5- HT3- like receptors may contribute to its increased antipsychotic efficacy.

Action of serotonin in the medial prefrontal cortex: Mediation by serotonin3‐like receptors

TLDR
5‐HT's physiological effect in the mPFc may be primarily mediated by its interaction with 5‐HT3‐like receptors and that ritanserin's blockade of CLi‐induced suppression of m PFc cell firing may be indirect.

Electrophysiological effects of selective D1 and D2 dopamine receptor agonists in the medial prefrontal cortex of young and aged Fischer 344 rats.

TLDR
It is suggested that both D1 and D2 receptors are present in the PFC and that agonist occupancy of each of these receptors elicits an inhibition of PFC neuron discharge, and an age-related change in D1 dopamine receptor-mediated processes with no concomitant change in processes linked to the activation of D2 dopamine processes is suggested.

Electrophysiological characterization of 5-hydroxytryptamine2 receptors in the rat medial prefrontal cortex.

TLDR
Overall the results indicate that DOI predominantly inhibits mPFc cells in a direct manner and this effect is mediated by 5-HT2 receptors.

Comparison of the effects of various typical and atypical antipsychotic drugs on the suppressant action of 2‐methylserotonin on medial prefrontal cortical cells in the rat

TLDR
The results suggest that the majority of putative atypical APDs do not interact with 5‐HT3 binding sites in the brain.