Clozapine as a drug of dependence

@article{Goudie1999ClozapineAA,
  title={Clozapine as a drug of dependence},
  author={Andrew J. Goudie and Judith A. Smith and Alex Robertson and Clare Cavanagh},
  journal={Psychopharmacology},
  year={1999},
  volume={142},
  pages={369-374}
}
Rationale: In schizophrenics, clozapine has been reported to induce various withdrawal signs and rapid onset relapse to psychosis on cessation of chronic treatment. Objective: The study was designed to develop an animal model of one aspect of clozapine tolerance and withdrawal using core body temperature measures. Methods: Two groups of 15 female Wistar rats were treated chronically (b.i.d.) with clozapine at 6 or 12 mg/kg per injection for 21 days prior to cessation of drug treatment… CONTINUE READING

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