Clozapine and haloperidol differentially affect AMPA and kainate receptor subunit mRNA levels in rat cortex and striatum.

@article{Healy1997ClozapineAH,
  title={Clozapine and haloperidol differentially affect AMPA and kainate receptor subunit mRNA levels in rat cortex and striatum.},
  author={Daniel Joseph Healy and James H. Meador-Woodruff},
  journal={Brain research. Molecular brain research},
  year={1997},
  volume={47 1-2},
  pages={
          331-8
        }
}
Dopamine is the neurotransmitter most often implicated in the pathogenesis of schizophrenia. However, glutamatergic antagonists can cause psychotic symptoms in otherwise normal humans, and exacerbate these symptoms in schizophrenics. These findings have led to a model of dopamine-glutamate interactions in limbic cortex and striatum as a potential substrate for symptom production in schizophrenia. From this model, we might expect that cortical and striatal expression of non-NMDA ionotropic… CONTINUE READING
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