Clozapine administered once versus twice daily: does it make a difference?

@article{Procyshyn2014ClozapineAO,
  title={Clozapine administered once versus twice daily: does it make a difference?},
  author={Ric M Procyshyn and Fidel Vila-Rodriguez and William Honer and Alasdair M. Barr},
  journal={Medical hypotheses},
  year={2014},
  volume={82 2},
  pages={225-8}
}
Clozapine, generally considered to be the most effective antipsychotic, is the gold standard for treatment-resistant schizophrenia. With a relatively short half-life of 12h and a very quick dissociation rate from the dopamine D2 receptor, pharmacokinetic and pharmacodynamics principles would dictate that clozapine be administered twice daily. However, due… CONTINUE READING