Clozapine Rechallenge After Major Adverse Effects: Clinical Guidelines Based on 259 Cases

@article{Manu2018ClozapineRA,
  title={Clozapine Rechallenge After Major Adverse Effects: Clinical Guidelines Based on 259 Cases},
  author={P. Manu and Yevgeniya Lapitskaya and Atef Shaikh and J. Nielsen},
  journal={American Journal of Therapeutics},
  year={2018},
  volume={25},
  pages={e218–e223}
}
  • P. Manu, Yevgeniya Lapitskaya, +1 author J. Nielsen
  • Published 2018
  • Medicine
  • American Journal of Therapeutics
  • Background: Clozapine is widely prescribed for treatment-refractory schizophrenia, but its use is limited by many potentially life-threatening adverse effects. The risk of rechallenge after these complications has never been comprehensively assessed in controlled studies. Thus, clinical guidelines must rely on the published case reports. The number of such reports is likely to increase over time, and updated analyses of larger samples are needed, as they may lead to changes in clinical… CONTINUE READING
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