Clozapine: selective labeling of sites resembling 5HT6 serotonin receptors may reflect psychoactive profile.

@article{Glatt1995ClozapineSL,
  title={Clozapine: selective labeling of sites resembling 5HT6 serotonin receptors may reflect psychoactive profile.},
  author={Charles E. Glatt and Adele M. Snowman and David R. Sibley and Solomon H Snyder},
  journal={Molecular medicine},
  year={1995},
  volume={1 4},
  pages={
          398-406
        }
}
BACKGROUND Clozapine, the classic atypical neuroleptic, exerts therapeutic actions in schizophrenic patients unresponsive to most neuroleptics. Clozapine interacts with numerous neurotransmitter receptors, and selective actions at novel subtypes of dopamine and serotonin receptors have been proposed to explain clozapine's unique psychotropic effects. To identify sites with which clozapine preferentially interacts in a therapeutic setting, we have characterized clozapine binding to brain… CONTINUE READING
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