Clozapine: A Novel Antipsychotic Agent

  title={Clozapine: A Novel Antipsychotic Agent},
  author={E Bablenis and Stanley S. Weber and Richard L. Wagner},
  booktitle={DICP : the annals of pharmacotherapy},
Clozapine is an antipsychotic without the extrapyramidal adverse effects associated with currently marketed antipsychotics. In animals, this drug has not been shown to induce catalepsy and only weakly antagonizes the stereotypic movements induced by apomorphine and the amphetamines. Clozapine is rapidly absorbed after both single and repeated oral doses, with steady-state concentrations attained within eight to ten days after beginning therapy. It is metabolized to N-oxideclozapine and N… 

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