Clozapine: A Novel Antipsychotic Agent

@inproceedings{Bablenis1989ClozapineAN,
  title={Clozapine: A Novel Antipsychotic Agent},
  author={E. Bablenis and S. S. Weber and R. Wagner},
  booktitle={DICP : the annals of pharmacotherapy},
  year={1989}
}
  • E. Bablenis, S. S. Weber, R. Wagner
  • Published in
    DICP : the annals of…
    1989
  • Medicine
  • Clozapine is an antipsychotic without the extrapyramidal adverse effects associated with currently marketed antipsychotics. In animals, this drug has not been shown to induce catalepsy and only weakly antagonizes the stereotypic movements induced by apomorphine and the amphetamines. Clozapine is rapidly absorbed after both single and repeated oral doses, with steady-state concentrations attained within eight to ten days after beginning therapy. It is metabolized to N-oxideclozapine and N… CONTINUE READING
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