Clove cigarette smoking: biochemical, physiological, and subjective effects

@article{Malson2003CloveCS,
  title={Clove cigarette smoking: biochemical, physiological, and subjective effects},
  author={Jennifer L Malson and Eun M Lee and Ramachandra Murty and Eric T. Moolchan and Wallace B. Pickworth},
  journal={Pharmacology Biochemistry and Behavior},
  year={2003},
  volume={74},
  pages={739-745}
}
Alternative tobacco products such as clove (kreteks) and bidi cigarettes have become increasingly popular among US smokers. The nicotine content of a popular clove cigarette (Djarum Special) filler averaged 7.4 mg; conventional cigarettes contained 13.0 mg. However, smoke yields from standardized machine-smoking analysis indicated it delivered more nicotine, carbon monoxide (CO), and tar than conventional cigarettes. In a clinical study, nicotine delivery, physiologic, and subjective effects of… 
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References

SHOWING 1-10 OF 23 REFERENCES
Nicotine delivery from smoking bidis and an additive-free cigarette.
TLDR
Overall, the results indicate that bidis and the additive-free cigarette delivered nicotine, CO and (presumably) other toxic components of tobacco smoke in equal or greater amounts than conventional cigarettes.
Sensory and physiologic effects of menthol and nonmenthol cigarettes with differing nicotine delivery
TLDR
It is indicated that nicotine delivery, but not mentholation, influences cardiovascular and most subjective measures, and the importance of threshold levels of nicotine on subjective responses to cigarette smoking is illustrated.
Bidis—hand-rolled, Indian cigarettes: Effects on physiological, biochemical and subjective measures
TLDR
Although time to smoke and puffs per cigarette were significantly higher after the bidi, physiological and biochemical effects of bidi smoking were similar to those of smoking conventional cigarettes.
Pharmacodynamic effects of new de-nicotinized cigarettes.
TLDR
The de-nicotinized cigarettes may prove useful in evaluating effects of smoking independent of the delivery of nicotine, and extend previous research that suggested the process of smoking and components of tobacco smoke other than nicotine mediate some effects of cigarette smoking.
Comparison of the nicotine content of tobacco used in bidis and conventional cigarettes
TLDR
Bidi cigarettes contain higher concentrations of nicotine than conventional cigarettes, and it is logical to presume that bidi smokers are at risk of becoming nicotine dependent.
Dissociating nicotine and nonnicotine components of cigarette smoking
To dissociate the sensorimotor aspects of cigarette smoking from the pharmacologic effects of nicotine, smokers rated the subjective effects of nicotine-containing or denicotinized cigarettes, and
Transdermal nicotine: reduction of smoking with minimal abuse liability
TLDR
Large changes in venous plasma nicotine levels engender only modest changes in ad libitum cigarette consumption, measures of abuse liability and cardiovascular effects, consistent with the notion that the addictive and toxic effects of nicotine are partially determined by the rate of drug administration.
Intravenous nicotine replacement suppresses nicotine intake from cigarette smoking.
TLDR
Down-regulation of levels of nicotine while smoking in response to infusion of nicotine was imprecise, which may be a result of psychosocial factors influencing smoking behavior along with the development of tolerance to toxic effects of nicotine as a consequence of prolonged exposure to nicotine.
Suppression of nicotine intake during ad libitum cigarette smoking by high-dose transdermal nicotine.
TLDR
High-dose transdermal nicotine has the potential to substantially suppress the intake of tobacco smoke and could be a useful strategy for smoking cessation therapy or for reducing the harm caused by smoking.
Individual differences in smoking reward from de-nicotinized cigarettes.
TLDR
A major finding of this analysis is that ratings of smoking derived from de-nicotinized, but not nicotine-containing, cigarettes appear to vary with level of tobacco dependence, suggesting that sensory factors may be more important to highly dependent, as compared to less-dependent, smokers.
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