Personalized Medicine and Whole Genome Sequencing in the Era of Big Data : Challenges and Opportunities
- Gary E . Marchant, Gillian Bartlett - Esquilant, Martin Dawes, Amalia M . Issa
In the race between DNA sequencing throughput and computer speed, sequencing is winning by a mile. Sequencing throughput has recently been improving at a rate of about 5fold per year1, while computer performance generally follows “Moore's Law,” doubling only every 18 or 24 months2. As this gap widens, the question of how to design higherthroughput analysis pipelines becomes critical. If analysis throughput fails to turn the corner, research projects will continually stall until analyses catch up.