Clotrimazole decreases human breast cancer cells viability through alterations in cytoskeleton-associated glycolytic enzymes.

@article{Meira2005ClotrimazoleDH,
  title={Clotrimazole decreases human breast cancer cells viability through alterations in cytoskeleton-associated glycolytic enzymes.},
  author={D{\'e}bora Dummer Meira and M{\^o}nica Mesquita Marinho-Carvalho and Cesar Augusto Antunes Teixeira and Venicio F. Veiga and Andrea T Da Poian and Carla Holandino and Marta Sampaio de Freitas and Mauro Sola-Penna},
  journal={Molecular genetics and metabolism},
  year={2005},
  volume={84 4},
  pages={354-62}
}
Cancer cells are characterized by a high rate of glycolysis, which is their primary energy source. Glycolysis is known to be controlled by allosteric regulators, as well as by reversible binding of glycolytic enzymes to cytoskeleton. Clotrimazole is an anti-fungal azole derivative recently recognized as a calmodulin antagonist with promising anti-cancer effect. Here, we show that clotrimazole induced morphological and functional alterations on human breast cancer derived cell line, MCF-7. The… CONTINUE READING
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