Clotiapine compared with chlorpromazine in chronic schizophrenia

  title={Clotiapine compared with chlorpromazine in chronic schizophrenia},
  author={Vadim Geller and Igor Gorzaltsan and Tatiana Shleifer and R. H. Belmaker and Yuly Bersudsky},
  journal={Schizophrenia Research},

Chlorpromazine versus clotiapine for schizophrenia.

Results in this review suggest chlorpromazine and clotiapine cause similar adverse effects, although the quality of evidence for this is poor, making firm conclusions difficult.

Clotiapine in schizophrenia: a guide to its use

Clotiapine is a classic antipsychotic with properties similar to those of the typical phenothiazine antipsychotics, but that also exhibits some clozapine-like effects. Although clinical evidence from

Simultaneous analysis of classical neuroleptics, atypical antipsychotics and their metabolites in human plasma

The method was applied with success to plasma samples from schizophrenic patients undergoing polypharmacy with two or more different antipsychotics, suitable for the therapeutic drug monitoring (TDM) of the analytes in psychotic patients’ plasma.

Current awareness in human psychopharmacology

The bibliography contains newly published material in the field of human psychopharmacology that is relevant to any one of these headings, and if, in the preceding period, no publications are located relevant to this section, that section will be omitted.

Development and Validation of a GC-MS Method for the Detection and Quantification of Clotiapine in Blood and Urine Specimens and Application to a Postmortem Case

A reliable GC-MS method for the detection and quantification of clotiapine in blood and urine samples has been developed and fully validated and then applied to a postmortem case.

1,5‐Benzoxazepines as a unique and potent scaffold for activity drugs: A review

This article is the first review publication to describe the synthesis methods and unique properties of 1,5‐benzoxazepine derivatives, which have interesting biological and pharmacological properties.

3.0 T fMRI in Psychiatry

Noninvasive imaging techniques including functional magnetic resonance imaging (fMRI) are crucial tools in order to shape functional aspects of the brain likely at the basis of emergent phenomena characterizing the clinical presentation of psychiatric disorders.

Electrochemical lithiation of silicon electrodes: neutron reflectometry and secondary ion mass spectrometry investigations

Abstract In-situ neutron reflectometry and ex-situ secondary ion mass spectrometry in combination with electrochemical methods were used to study the lithiation of amorphous silicon electrodes. For



Clotiapine: An old neuroleptic with possible clozapine-like properties

Is it possible to predict the clinical effects of neuroleptics from animal data? Part V: From haloperidol and pipamperone to risperidone.

As shown by the present analysis of relative tryptamine versus apomorphine antagonism of 57 neuroleptics, in comparison to relative S2 vs. D2 binding, there is a continuity in the series.

Electrocardiographic changes during desipramine and clomipramine treatment in children and adolescents.

CMI and DMI both produced ECG changes typically reported for tricyclic antidepressants, and they differed on specific ECGs changes, suggesting that continued monitoring is required.

Which atypical antipsychotics are identified by screening tests?

It is proposed to develop research protocols to assess their efficacy in treatment-resistant psychoses and intractable conditions such as tardive dyskinesia and to review the literature on the clinical use of the compounds identified as atypical.

Case study: emergence of transient compulsive symptoms during treatment with clothiapine.

It seems that antagonistic activity of atypical neuroleptics at postsynaptic serotonergic receptors might be responsible for the development of iatrogenic obsessive-compulsive symptoms.

A survey of psychotropic medications not available in the United States.

This survey identifies some specific non-U.S. drugs of interest that have been "me too" drugs, offering primarily side-effect differences, instead of new indications or mechanisms, that are not available in the United States.

Research in schizophrenia and the discontinuation of antipsychotic medications.

  • R. Wyatt
  • Medicine, Psychology
    Schizophrenia bulletin
  • 1997
The concept that at least some forms of schizophrenia are progressive is reviewed, with the view that early intervention improves the long-term course of the illness and whether withdrawal of antipsychotic medications increases long- term morbidity.

Mechanism of atypicality of antipsychotic drugs

Effect of typical and atypical antipsychotic drugs on 5-HT2 receptor density in rat cerebral cortex.

A meta-analysis of the efficacy of second-generation antipsychotics