Clostridium septicum alpha toxin uses glycosylphosphatidylinositol-anchored protein receptors.

@article{Gordon1999ClostridiumSA,
  title={Clostridium septicum alpha toxin uses glycosylphosphatidylinositol-anchored protein receptors.},
  author={Victor M. Gordon and Kathryn L Nelson and J. Thomas Buckley and Vanessa L Stevens and Rodney K. Tweten and Patrick C Elwood and Stephen H Leppla},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 38},
  pages={27274-80}
}
The alpha toxin produced by Clostridium septicum is a channel-forming protein that is an important contributor to the virulence of the organism. Chinese hamster ovary (CHO) cells are sensitive to low concentrations of the toxin, indicating that they contain toxin receptors. Using retroviral mutagenesis, a mutant CHO line (BAG15) was generated that is resistant to alpha toxin. FACS analysis showed that the mutant cells have lost the ability to bind the toxin, indicating that they lack an alpha… CONTINUE READING
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Receptors for C. septicum Alpha Toxin 27280 by gest on A uust 16

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