Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens[S]

@inproceedings{Ridlon2013ClostridiumSA,
  title={Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens[S]},
  author={Jason M. Ridlon and Shigeo Ikegawa and Jo{\~a}o M P Alves and Biao Zhou and Akiko Kobayashi and Takashi Iida and Kuniko Mitamura and Genzoh Tanabe and Myrna G. Serrano and Ainee De Guzman and Patsy Cooper and Gregory A. Buck and Phillip B. Hylemon},
  booktitle={Journal of lipid research},
  year={2013}
}
Clostridium scindens American Type Culture Collection 35704 is capable of converting primary bile acids to toxic secondary bile acids, as well as converting glucocorticoids to androgens by side-chain cleavage. The molecular structure of the side-chain cleavage product of cortisol produced by C. scindens was determined to be 11β-hydroxyandrost-4-ene-3,17-dione (11β-OHA) by high-resolution mass spectrometry, (1)H and (13)C NMR spectroscopy, and X-ray crystallography. Using RNA-Seq technology, we… CONTINUE READING
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