Clostridium perfringens iota-toxin requires activation of both binding and enzymatic components for cytopathic activity.

@article{Gibert2000ClostridiumPI,
  title={Clostridium perfringens iota-toxin requires activation of both binding and enzymatic components for cytopathic activity.},
  author={Maryse Gibert and Laetitia Marie Petit and St{\'e}phanie Raffestin and Akinobu Okabe and Michel Robert Popoff},
  journal={Infection and immunity},
  year={2000},
  volume={68 7},
  pages={3848-53}
}
Iota-toxin is produced by Clostridium perfringens type E strains and consists of two independent components, the enzymatic and binding components, referred to as Ia and Ib, respectively. A recombinant C. perfringens strain, strain 667/pMRP147, produced processed Ia and partially processed Ib, while a recombinant C. perfringens type A strain, strain TS133/pMRP147, in which the VirR-VirS two-component system is inactivated, produced only precursor forms of Ia and Ib. This suggests that iota-toxin… CONTINUE READING