Clostridium perfringens epsilon toxin causes excessive release of glutamate in the mouse hippocampus.

@article{Miyamoto2000ClostridiumPE,
  title={Clostridium perfringens epsilon toxin causes excessive release of glutamate in the mouse hippocampus.},
  author={O. Miyamoto and Kazunori Sumitani and Takeshi Nakamura and Sakae Yamagami and Seiji Miyata and Toshifumi Itano and Tetsuro Negi and Akinobu Okabe},
  journal={FEMS microbiology letters},
  year={2000},
  volume={189 1},
  pages={
          109-13
        }
}
The mechanism of neurotoxicity of Clostridium perfringens epsilon toxin to the mouse brain was investigated. Intravenous injection in mice with the toxin caused seizure and excited hippocampal neurons. Microdialysis revealed that epsilon toxin induced excessive glutamate release in the hippocampus. Both the seizure and glutamate release were attenuated by prior injection with riluzole, an inhibitor of pre-synaptic glutamate release, suggesting that this toxin enhances glutamate efflux, leading… CONTINUE READING

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