Clostridium perfringens enterotoxin interacts with claudins via electrostatic attraction.

@article{Kimura2010ClostridiumPE,
  title={Clostridium perfringens enterotoxin interacts with claudins via electrostatic attraction.},
  author={Jun Kimura and Hiroyuki Abe and Shigeki Kamitani and Hirono Toshima and Aya Fukui and Masami Miyake and Yoichi Kamata and Yoshiko Sugita-Konishi and Shigeki Yamamoto and Yasuhiko Horiguchi},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 1},
  pages={401-8}
}
Clostridium perfringens enterotoxin (CPE), a causative agent of food poisoning, is a pore-forming toxin disrupting the selective permeability of the plasma membrane of target cells, resulting in cell death. We previously identified claudin as the cell surface receptor for CPE. Claudin, a component of tight junctions, is a tetratransmembrane protein and constitutes a large family of more than 20 members, not all of which serve as the receptor for CPE. The mechanism by which the toxin… CONTINUE READING

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