Clostridium perfringens enterotoxin interacts with claudins via electrostatic attraction.

  title={Clostridium perfringens enterotoxin interacts with claudins via electrostatic attraction.},
  author={Jun Kimura and Hiroyuki Abe and Shigeki Kamitani and Hirono Toshima and Aya Fukui and Masami Miyake and Yoichi Kamata and Yoshiko Sugita-Konishi and Shigeki Yamamoto and Yasuhiko Horiguchi},
  journal={The Journal of biological chemistry},
  volume={285 1},
Clostridium perfringens enterotoxin (CPE), a causative agent of food poisoning, is a pore-forming toxin disrupting the selective permeability of the plasma membrane of target cells, resulting in cell death. We previously identified claudin as the cell surface receptor for CPE. Claudin, a component of tight junctions, is a tetratransmembrane protein and constitutes a large family of more than 20 members, not all of which serve as the receptor for CPE. The mechanism by which the toxin… CONTINUE READING


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Biochemical pharmacology

C. Ebihara, M. Kondoh, +6 authors Y. Watanabe

Paradigms and classification of bacterial membrane-damaging toxins

J. E. Alouf
View 1 Excerpt

Repertoire and general features of the family of cholesterol-dependent cytolysins. in The comprehensive sourcebook of bacterial protein toxins

J. E. Alouf, S. J. Billington, B. H. Jost
View 1 Excerpt

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