Clostridium perfringens alpha-toxin recognizes the GM1a-TrkA complex.

@article{Oda2012ClostridiumPA,
  title={Clostridium perfringens alpha-toxin recognizes the GM1a-TrkA complex.},
  author={Masataka Oda and Michiko Kabura and Teruhisa Takagishi and Ayaka Suzue and Kaori Tominaga and Shiori Urano and Masahiro Nagahama and Keiko Kobayashi and Keiko Furukawa and Koichi Furukawa and Jun Sakurai},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 39},
  pages={
          33070-9
        }
}
Clostridium perfringens alpha-toxin is the major virulence factor in the pathogenesis of gas gangrene. Alpha-toxin is a 43-kDa protein with two structural domains; the N-domain contains the catalytic site and coordinates the divalent metal ions, and the C-domain is a membrane-binding site. The role of the exposed loop region (72-93 residues) in the N-domain, however, has been unclear. Here we show that this loop contains a ganglioside binding motif (H … SXWY … G) that is the same motif seen in… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 19 CITATIONS

Preparation and characterization of a human scFv against the Clostridium perfringens type A alpha‐toxin

VIEW 1 EXCERPT
CITES BACKGROUND