Clostridium perfringens alpha-toxin: characterization and mode of action.

@article{Sakurai2004ClostridiumPA,
  title={Clostridium perfringens alpha-toxin: characterization and mode of action.},
  author={Jun Sakurai and Masahiro Nagahama and Masataka Oda},
  journal={Journal of biochemistry},
  year={2004},
  volume={136 5},
  pages={
          569-74
        }
}
Clostridium perfringens type A strains that produce alpha-toxin cause gas gangrene, which is a life-threatening infection with fever, pain, edema, myonecrosis and gas production. Intramuscular injection of the toxin or Bacillus subtilis carrying the alpha-toxin gene causes myonecrosis and produces histopathological features of the disease. Immunization of mice with alpha-toxin or fragments of the toxin prevents gas gangrene caused by C. perfringens. The toxin possesses phospholipase C (PLC… Expand
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