Clostridium difficile toxin expression is inhibited by the novel regulator TcdC.

@article{Matamouros2007ClostridiumDT,
  title={Clostridium difficile toxin expression is inhibited by the novel regulator TcdC.},
  author={Susana Matamouros and Patrick England and Bruno Dupuy},
  journal={Molecular microbiology},
  year={2007},
  volume={64 5},
  pages={1274-88}
}
Clostridium difficile, an emerging nosocomial pathogen of increasing clinical significance, produces two large protein toxins that are responsible for the cellular damage associated with the disease. The precise mechanisms by which toxin synthesis is regulated in response to environmental change have yet to be discovered. The toxin genes (tcdA and tcdB) are located in a pathogenicity locus (PaLoc), along with tcdR and tcdC. TcdR is an alternative RNA polymerase sigma factor that directly… CONTINUE READING
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