Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers.

@article{Hecht1988ClostridiumDT,
  title={Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers.},
  author={Gail A. Hecht and Charalabos Pothoulakis and John Thomas Lamont and James L. Madara},
  journal={The Journal of clinical investigation},
  year={1988},
  volume={82 5},
  pages={1516-24}
}
Toxin A of Clostridium difficile causes severe inflammatory enterocolitis in man and animals that appears to be mediated in part by acute inflammatory cells that migrate into the toxin A-exposed mucosa. To determine the direct effects of toxin A on intestinal epithelial permeability and structure in the absence of other modulating factors, we used cultured monolayers of a human intestinal epithelial cell line (T84). A toxin A concentration of 7 x 10(-1) micrograms/ml (3 x 10(-9) M) nearly… CONTINUE READING

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