Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase.

@article{Kim2005ClostridiumDT,
  title={Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase.},
  author={H. Katherine Kim and Efi G Kokkotou and Xi Na and Sang Hoon Rhee and Mary Pat Moyer and Charalabos Pothoulakis and John Thomas Lamont},
  journal={Gastroenterology},
  year={2005},
  volume={129 6},
  pages={1875-88}
}
BACKGROUND & AIMS Clostridium difficile toxin A causes marked apoptosis of colonocytes in vivo and in vitro, which contributes to the formation of ulcers and pseudomembranes. We investigated the role of p53-dependent pathways and p38 mitogen-activated protein kinase (p38) in toxin A-induced colonocyte apoptosis. METHODS The effects of the activation of p53 and p53-dependent pathways including p21(WAF1/CIP1) were assessed in nontransformed human colonic NCM460 epithelial cells exposed to toxin… CONTINUE READING