Clostridium difficile invasion and toxin circulation in fatal pediatric pseudomembranous colitis.

@article{Qualman1990ClostridiumDI,
  title={Clostridium difficile invasion and toxin circulation in fatal pediatric pseudomembranous colitis.},
  author={Stephen J. Qualman and Martin Petric and Mohamed Karmali and Craig J Smith and Stanley R. Hamilton},
  journal={American journal of clinical pathology},
  year={1990},
  volume={94 4},
  pages={
          410-6
        }
}
The direct involvement of Clostridium difficile in the lesional tissue of pseudomembranous colitis has not been demonstrated; the organism's effects have been assumed to be strictly toxin mediated. Because C. difficile cytotoxin may be found incidentally in the intestinal lumina of asymptomatic infants, the role of the organism in a variety of pediatric intestinal diseases is uncertain. The authors studied seven cases of fatal pediatric pseudomembranous colitis in which the presence of C… CONTINUE READING

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