Clostridium difficile infection: new approaches to prevention, non-antimicrobial treatment, and stewardship

@article{Cataldo2017ClostridiumDI,
  title={Clostridium difficile infection: new approaches to prevention, non-antimicrobial treatment, and stewardship},
  author={Maria Adriana Cataldo and Guido Granata and Nicola Petrosillo},
  journal={Expert Review of Anti-infective Therapy},
  year={2017},
  volume={15},
  pages={1027 - 1040}
}
ABSTRACT Introduction: Despite the large amount of scientific publications exploring the epidemiology and the clinical management of Clostridium difficile (CD) infection, some issues remain unsolved or need further studies. The aim of this review is to give an update on the hot topics on CD prevention, including stewardship programs, and on the non-microbiological treatment of CD infection. Areas covered: This article will review the importance of minimizing the CD spore shedding in the… 
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Clinical impact of a Clostridioides (Clostridium) difficile bedside infectious disease stewardship intervention
TLDR
A bedside rapid intervention for patients with a CDI-positive faecal sample was effective in avoiding overdiagnosis and unnecessary antibiotic treatment, optimizing anti-CDI drugs, increasing compliance with infection control measures and providing educational advice.
RISK FACTORS FOR rCDI
  • 2019
Recurrent Clostridium difficile Infection: Risk Factors, Treatment, and Prevention
TLDR
The risk factors, treatment, and prevention of rCDI are reviewed and several treatment modalities, including vancomycin, fidaxomicin, and fecal microbiota transplant (FMT), are suggested for r CDI treatment.
Novel Antimicrobials for the Treatment of Clostridium difficile Infection
TLDR
The novel antimicrobial molecules under development for CDI have promising key features and advancements in comparison to the traditional anti-CDI antimicrobials and in the near future, some of these new molecules might be effective alternatives to fight CDI.
Clostridium difficile and One Health.
  • S. Lim, D. Knight, T. Riley
  • Medicine, Biology
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • 2019
Treatment Options for Colistin Resistant Klebsiella pneumoniae: Present and Future
TLDR
This review describes the features of colistin resistance in K. pneumoniae and the characteristics of the currently available antimicrobials forcolistin-resistant MDR K. tuberculosis, as well as the characteristic of novel antimicrobial options, such as the soon-to-be commercially available plazomicin and cefiderocol.
The burden of Clostridioides difficile infection in COVID-19 patients: A systematic review and meta-analysis
How Does COVID-19 Pandemic Impact on Incidence of Clostridioides difficile Infection and Exacerbation of Its Gastrointestinal Symptoms?
TLDR
The main purpose of this review is to explain the likely risk factors contributing to higher incidence of CDI in patients with COVID-19 and to remain vigilant for possible SARS-CoV-2 and CDI coinfection during the ongoing CO VID-19 pandemic and the excessive use of antimicrobials and biocides.
The Burden of Clostridioides Difficile Infection during the COVID-19 Pandemic: A Retrospective Case-Control Study in Italian Hospitals (CloVid)
TLDR
CDI complicates COVID-19, mainly in patients with co-morbidities and previous healthcare exposures, and its association with antibiotic usage and hospital acquired bacterial infections should lead to strengthen antimicrobial stewardship programmes and infection prevention and control activities.
Heterocycle compounds with antimicrobial activity.
TLDR
Despite the progress in the development of new antimicrobial agents there is still room for new findings among five-membered heterocyclic compounds, according to a literature survey that covers the last decade.
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References

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TLDR
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TLDR
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