Clostridium difficile: controversies and approaches to management

@article{Bauer2009ClostridiumDC,
  title={Clostridium difficile: controversies and approaches to management},
  author={M. Bauer and J. V. van Dissel and E. Kuijper},
  journal={Current Opinion in Infectious Diseases},
  year={2009},
  volume={22},
  pages={517–524}
}
Purpose of review The increasing incidence of Clostridium difficile infection (CDI) is confronting us with two major problems in CDI management that presently remain unsolved: refractoriness to therapy and recurrence of disease. This review focuses on recent insights in antimicrobial therapy of CDI, as well as advances in alternative treatment modalities. Recent findings In severe CDI, oral vancomycin has shown its superiority over metronidazole in two independent trials. Of new antimicrobials… Expand
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