Clostridium difficile: clinical disease and diagnosis.

  title={Clostridium difficile: clinical disease and diagnosis.},
  author={Floyd C. Knoop and Marilyn Owens and I C Crocker},
  journal={Clinical microbiology reviews},
  volume={6 3},
Clostridium difficile is an opportunistic pathogen that causes a spectrum of disease ranging from antibiotic-associated diarrhea to pseudomembranous colitis. Although the disease was first described in 1893, the etiologic agent was not isolated and identified until 1978. Since clinical and pathological features of C. difficile-associated disease are not easily distinguished from those of other gastrointestinal diseases, including ulcerative colitis, chronic inflammatory bowel disease, and Crohn… CONTINUE READING
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