Clostridium botulinum can grow and form toxin at pH values lower than 4.6

  title={Clostridium botulinum can grow and form toxin at pH values lower than 4.6},
  author={G. J. Raatjes and J. Smelt},
  • G. J. Raatjes, J. Smelt
  • Published 1979
  • Chemistry, Medicine
  • Nature
  • It is generally accepted1 that in Clostridium botulinum both growth and toxin formation are completely inhibited at pH values below 4.6. This critical pH value has been confirmed by many investigators using food as substrate2–5 or culture media3,6–8. Occasionally9–12 growth of C. botulinum and toxin formation at pH values lower than 4.6 have been reported. In these cases the authors ascribed the unexpected outgrowth and toxin formation to local pH differences in inhomogeneous media and growth… CONTINUE READING
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