Clostridium botulinum: A Bug with Beauty and Weapon

@article{Shukla2005ClostridiumBA,
  title={Clostridium botulinum: A Bug with Beauty and Weapon},
  author={Hem D Shukla and S. Sharma},
  journal={Critical Reviews in Microbiology},
  year={2005},
  volume={31},
  pages={11 - 18}
}
  • H. Shukla, S. Sharma
  • Published 1 January 2005
  • Biology, Medicine
  • Critical Reviews in Microbiology
Clostridium botulinum, a Gram-positive, anaerobic spore-forming bacteria, is distinguished by its significant clinical applications as well as its potential to be used as bioterror agent. [...] Key Result The bacterium harbors a 16.3 kb plasmid with a 26.8% G+C content--slightly lower than that of the chromosome.Expand
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TLDR
The use of a single lateral flow device that can detect and distinguish between BoNT/A and B, two of the four serotypes that are known to intoxicate humans and together represent >80% of naturally occurring illness, is described.
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TLDR
An important observation of the anti-apoptotic effect of Hemagglutinin-33 in Hn-33-preincubated human neuroblastoma SH-SY5Y cells is reported, which may have significant implications to the use of BoNT as a therapeutic agent, and to devise counter measures to botulinum poisoning.
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Trends in the therapy of botulism
Botulin neurotoxins are etiological agents of botulism, which is a disease manifested by peripheral neuromuscular blockage and characterized by plegia. Botulotoxin is the most toxic known substance.
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TLDR
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ORAL LD50 OF BOTULINUM TOXIN SEROTYPE A IN GUINEA PIGS
TLDR
The goal of this study was to assess whether fresh 2% milk provided protective qualities to Botulinum toxin serotype A (B0NT/A) against degradation in the gastrointestinal tract and if protected this would lead to half of the tested population being killed with lower doses compared to toxin delivered in a conventional delivery vehicle.
Host Response to Botulinum Neurotoxins for Developing Diagnostics and Antidotes
TLDR
Two recombinant proteins are produced - a mutant BoNT/A that lacks the endopeptidase activity, and the hemagglutinin 33 (Hn-33), the most abundant component of NAPs, to investigate host-response to the exposure of botulinum neurotoxin and its neurotoxin associated proteins.
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