Clostridial neurotoxins as tools to investigate the molecular events of neurotransmitter release.

@article{Schiavo1994ClostridialNA,
  title={Clostridial neurotoxins as tools to investigate the molecular events of neurotransmitter release.},
  author={Giampietro Schiavo and Ornella Rossetto and Cesare Montecucco},
  journal={Seminars in cell biology},
  year={1994},
  volume={5 4},
  pages={221-9}
}
The clostridial neurotoxins responsible for tetanus and botulism are eight different proteins, composed of two disulfide-linked polypeptide chains. They bind specifically to the presynaptic membrane via the heavy chain, while the light chain enters the cytosol of the neurons, where it displays a zinc-endopeptidase activity directed to proteins of the neuroexocytosis apparatus. Tetanus neurotoxin and botulinum neurotoxin serotypes B, D, F and G cleave specifically and at single different peptide… CONTINUE READING

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Botulinum and Tetanus Neurotoxin-Induced Blockade of Synaptic Transmission in Networked Cultures of Human and Rodent Neurons.

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