Clostridial ADP-ribosylating toxins: effects on ATP and GTP-binding proteins

@article{Aktories1994ClostridialAT,
  title={Clostridial ADP-ribosylating toxins: effects on ATP and GTP-binding proteins},
  author={Klaus Aktories},
  journal={Molecular and Cellular Biochemistry},
  year={1994},
  volume={138},
  pages={167-176}
}
The actin cytoskeleton appears to be as the cellular target of various clostridial ADP-ribosyltransferases which have been described during recent years.Clostridium botulinum C2 toxin,Clostridium perfringens iota toxin andClostridium spiroforme toxin ADP-ribosylate actin monomers and inhibit actin polymerization.Clostridium botulium exoenzyme C3 andClostridium limosum exoenzyme ADP-ribosylate the low-molecular-mass GTP-binding proteins of the Rho family, which participate in the regulation of… CONTINUE READING

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