Clostridial ADP-ribosylating toxins: effects on ATP and GTP-binding proteins

  title={Clostridial ADP-ribosylating toxins: effects on ATP and GTP-binding proteins},
  author={Klaus Aktories},
  journal={Molecular and Cellular Biochemistry},
The actin cytoskeleton appears to be as the cellular target of various clostridial ADP-ribosyltransferases which have been described during recent years.Clostridium botulinum C2 toxin,Clostridium perfringens iota toxin andClostridium spiroforme toxin ADP-ribosylate actin monomers and inhibit actin polymerization.Clostridium botulium exoenzyme C3 andClostridium limosum exoenzyme ADP-ribosylate the low-molecular-mass GTP-binding proteins of the Rho family, which participate in the regulation of… CONTINUE READING


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